Two vehicles crashed head-on near the Central Avenue exit on eastbound I-475 around 2:30 a.m. Saturday.
Police say the driver of an SUV was heading westbound in the eastbound lanes when the driver crashed head-on with another car, killing that driver.
The person driving the SUV was transported to an area hospital with life threatening injuries.
Investigators are working to determine if alcohol played a role in the crash.
The drivers' names have not yet been released.